肺鳞30月，父亲永远地走了

# n: J. r; ^6 t! l. |3 }4.15 复查
医生认为CT才做一个月，结果稳定，这次查个血就够了，我认同，上次就CA125增长比较多，这次开单查了CEA、CA125、CA153、CA199，NSE。去年9月之前没记录，尚未找到规律，再来几次可能就知道哪个敏感了。
# j. L, `5 s  `' H6 I如果2992还有效，是否改成吃8停5？目前状态很好，乳铁蛋白有奇效？

4.17 昨天抽了血，今天出报告：
2 S3 I' ?' M/ JCEA 1.76
4 G7 R# `  J& g0 n9 k/ W' ]CA125 162.6 继续升高，估计2992耐药或部分耐药了
# U$ I. h3 m! e6 u- U/ S! oCA199 8.48
- z- }8 ^) B; XCA153 17.82
5 Z7 d! i" V# pNSE 14.95
$ y* k( W& P: E2 Y% m# i+ u

CT上个月做稳定，因此这次未做，CA125继续上升，纠结要不要化疗。医生提议目前生活质量很好，以CT为准，暂不管指标上升。
纠结ing

( w) v* @  d6 i4 {( B9 U" @
5 }) i9 P* Z& \( ^! _/ m现在考虑的方案：
: F1 v9 Y% T: H$ X7 G1、试试易(平安老师认为肺癌不试试易可惜）
9 |# ], J# D4 w- Q* W2、2992+半量xl184
3、2992加量
$ {" e9 p; j0 c8 z; E- g凡德有试过，无效
5 D! X; [) d8 D' p3 d

" _; C$ a# m1 {/ g爱老虎油！ 2013/4/17 星期三 18:56:31
& x3 M3 f1 O9 o# V: ^! d. c* ^易用过吗？没用过试试易吧，肺，不用易太可惜了
. ]  r& V* r) P- g* P, [  t滴水(luxd)  20:20:13
平安姐，我父亲是鳞、吸烟，是不是也试试
6 O6 V7 x3 B3 J; k6 U滴水(luxd)  20:34:25
+ w: e' H  f5 c1 v/ F  }之前就是考虑鳞+男性+吸烟，直接上的特。现在考虑：
9 g9 X) t$ H$ P" o# }1 X1、试试易
2、2992+半量xl184
3、2992加量
凡德有试过，无效
爱老虎油！  21:31:42
8 M7 I, f. C2 e8 X如果病情紧急就上2，不紧急就试试易
# p5 p3 N' L- ^

考虑方案4：替吉奥
/ C% `3 m3 j3 l2 d( ?  C& C
S-1, an oral fluoropyrimidine derivative, has been approved for the treatment of non-small cell lung cancer (NSCLC) in Japan. In the present study, the efficacy and safety of S-1 monotherapy for elderly patients with previously treated NSCLC were retrospectively evaluated, and the efficacy of S-1 monotherapy was compared by histopathological type. This retrospective study included 54 patients with advanced or recurrent NSCLC who had received S-1 monotherapy following the failure of previous chemotherapy regimens at our institutes. Patient outcomes were compared based on their age and histopathological type. S-1 was administered orally, twice daily, while the duration and interval were modified according to the medical condition of each patient. The default delivery schedule, the mean number of S-1 cycles, did not differ significantly between the two age groups (<70 and ≥70 years). The rate of therapy discontinuation, schedule modification or dose reduction due to intolerable toxicities or patient refusal was relatively frequent in the older group (40.7 and 55.6% for ages <70 and ≥70 years, respectively; p=0.414), and the incidence of grade 3 anemia was relatively high in the older group (3.7 and 18.5%, respectively; p=0.192). The response rates (13.0 and 4.8%, respectively; p=0.609) and disease control rates (39.1 and 33.3%, respectively; p=0.761) did not differ significantly between the two age groups. According to histopathological type, the disease control rate was significantly higher in adenocarcinoma (57.9%) compared to non-adenocarcinoma (20.0%, p=0.013). Thus, S-1 monotherapy may be equally effective and tolerated in patients <70 years and those ≥70 years. Additionally, adenocarcinoma may have a higher disease control rate than non-adenocarcinoma.

替的疾病控制率，腺比非腺高很多：57.9%vs20%

S-1联合铂类，效果与病理类型无关（即鳞和腺相当），这与培美不同，可能是作用TS的方式不同。
3 I8 G1 M: z' x7 A* Yhttp://ar.iiarjournals.org/content/30/7/2985.full.pdf
单药却与病理类型有关？

综合平安老师、老马建议和自己判断，决定采用方案四，口服替吉奥。原因：
1、特、2992均已耐药，易有效的可能性很低；
2、2992趋于耐药，如果没有有效手段，反正都要化疗了，口服替是比较轻松的化疗方案；
( R8 L' b6 Y3 H/ P* G4 j3、如果不准备把2992用绝，联用方案也先不考虑：
--2992+184，平安老师认为在危急的时候用；
) g4 n4 r1 w' b  M2 P. [/ c' Z--2992+替http://www.ncbi.nlm.nih.gov/pubmed/20530710，2992已经耐药，就先不考虑联用了；
( G) m/ h7 P0 g( o, ~5、如果替有效，那怕只是稳定，也为切换回特创造条件，如果无效，就去多西他赛化疗。
% H! D1 h' }; p' Y6 _还有什么要考虑的？每次情况变化，做决定都是犹豫不决。

4.22 开始替吉奥，60mg bid

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