发给老马备查:6 e8 Q+ T4 ]; |& ~- u8 [* }8 o* |
滴水察海(69304838) 15:23:23
2 N! m' n' O1 J' \老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱" i1 T' ~9 s8 b- V
吉非替尼和S-1连用的依据/ x9 M& `* q" d$ d; J {; E
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
6 b, x8 i! l1 |' d( m6 K2 T0 o& ^% {是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达3 G3 e( O* W/ o% v' k& I
这样是不是推理出,耐药后,可以用S-1和培美了?+ c/ j1 m& y! u
结论:
S. o2 {" K- J2 A9 _ O$ v7 O/ K如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |