发给老马备查:
1 g( T$ w! v" E7 s滴水察海(69304838) 15:23:23: l" n9 W1 S I6 H
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
' D' Q9 L Q7 j* {) o- a! c; J7 E吉非替尼和S-1连用的依据) O# h% { I) n& Z; ~! z. i
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.! @2 |3 }9 Q( @
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达/ J* {( {$ K! X9 y" b
这样是不是推理出,耐药后,可以用S-1和培美了?, T5 P7 _$ f' |; D: h' z& ]
结论:0 [. S& s, u8 w$ J* d$ K& ~
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |